Symptoms of AIDS
Clinical stages of HIV / AIDS by WHO
The World Health Organization in 1990 developed a clinical classification of HIV / AIDS, which was last significantly supplemented and updated in 2006 and published for European countries on December 1, 2006 in the “WHO Protocols for the Treatment and Prevention of HIV / AIDS”.
WHO clinical stages for adults and adolescents ≥ 15 years:
- Acute HIV infection
– Asymptomatic
– Acute retroviral syndrome - Clinical stage 1
– Asymptomatic
– Persistent generalized lymphadenopathy (PGL) - Clinical stage 2
– Seborrheic dermatitis
– Angular cheilitis
– Recurrent oral ulcers (two or more episodes within 6 months)
– Shingles (common herpes)
– Recurrent respiratory tract infections – sinusitis, otitis media, pharyngitis, bronchitis, tracheitis, (two or more episodes within 6 months)
– Fungal nail infections
– Papular itchy dermatitis - Clinical stage 3
– Hairy leukoplakia of the mouth
– Unexplained chronic diarrhea lasting more than 1 month
– Recurrent oral candidiasis (two or more episodes within 6 months)
– Severe bacterial infection (pneumonia, empyema, purulent myositis, bone or joint infections, meningitis, bacteremia)
– Acute necrotizing stomatitis, gingivitis or periodontitis - Clinical stage 4 (*)
– Pulmonary tuberculosis
– Extrapulmonary tuberculosis (excluding lymphadenopathy)
– Unexplained weight loss (more than 10% within 6 months)
– HIV wasting syndrome
– Pneumocystis pneumonia
– Severe or radiologically confirmed pneumonia (two or more episodes within 6 months)
– Cytomegalovirus retinitis (with or without colitis)
– herpes simplex virus (HSV) (chronic or persistent for more than 1 month)
– Encephalopathy
– Progressive multifocal leukoencephalopathy
– Kaposi’s sarcoma and other HIV-related malignant neoplasms
– Toxoplasmosis
– Disseminated fungal infection (candidiasis, histoplasmosis, coccidioidomycosis)
– Cryptosporidiosis
– Cryptococcal meningitis
– Infection caused by non-tuberculous mycobacteria, disseminated mycobacterium (MOTT)
(*) If supported by sufficient evidence may include: anal carcinoma and lymphoma (T-cell Hodgkin’s lymphoma)